![]() ![]() We outline milestones on the roadmap for the future development of disease maps, including creating and maintaining standardized disease maps sharing parts of maps that encode common human disease mechanisms providing technical solutions for complexity management of maps and Web tools for in-depth exploration of such maps. This article summarizes the 2nd Disease Maps Community meeting, highlighting its important topics and outcomes. Expert-curated and computer readable, disease maps may serve as a compendium of knowledge, allow for data-supported hypothesis generation or serve as a scaffold for the generation of predictive mathematical models. The involvement of domain experts ensures that the key disease hallmarks are covered and relevant, up-to-date knowledge is adequately represented. ![]() The primary focus of disease maps is on interconnected signaling, metabolic and gene regulatory network pathways represented in standard formats. The project aims for an integrated, highly curated and user-friendly platform for disease-related knowledge. The Disease Maps Project builds on a network of scientific and clinical groups that exchange best practices, share information and develop systems biomedicine tools. ![]()
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![]() ![]() ![]() This moved the new year from the end of March to the first of January, causing a great deal of confusion for some. He issued a decree ordering that all Christian nations adopt a standardized calendar, called the Gregorian calendar. It was Pope Gregory XIII who, in 1582, would unknowingly give rise to the world’s silliest holiday. The truth is, if you’ve ever pulled a gag or caused mischief on April Fool’s Day, you have the Catholic Church to thank, according to some historical accounts. It’s a free pass to play pranks and openly engage in tomfoolery, and who doesn’t love a good prank - or tomfoolery? In other news, the Pope has decreed Denver Catholic the greatest Catholic publication in the history of the world.Įverybody loves April Fool’s Day. The Denver Catholic would like to announce it will not be partaking in April Fool’s Day. ![]() ![]() ![]() Walter Isaacson is a master storyteller, a talent he so remarkable displays. The result is a gripping account of a great scientific advancement and of the dedicated scientists who realized it. The Code Breaker: Jennifer Doudna, Gene Editing, and the Future of the Human Race. But another scientist was granted a patent for using the tool. Born in 1964, Doudna grew up in Hawaii, where she felt isolated and, “like many others who have felt like an outsider, she developed a wide-ranging curiosity about how we humans fit into creation.” Praising her sharp mix of curiosity and competitiveness, Isaacson tracks her role in the race to develop CRISPR technology (which can easily and precisely cut human DNA sequences to change genes), explores the promises of the technique (such as potential cures for sickle cell anemia and cancer) and describes fears that it might herald a world of genetically engineered “designer babies.” Isaacson offers an impassioned take on CRISPR-“I look into the microscope and see them glowing green!” he remarks, peering at a culture of gene-edited cells-along with vivid portraits of the scientists Doudna worked with, including the “guarded but engaging” Emmanuelle Charpentier, with whom she won the Nobel Prize. Jennifer Doudna of the University of California at Berkeley was one of two women to share a Nobel prize for their work on CRISPR. ![]() Biographer Isaacson ( Leonardo da Vinci) depicts science at its most exhilarating in this lively biography of Jennifer Doudna, the winner of the 2020 Nobel Prize in chemistry for her work on the CRISPR system of gene editing. ![]() ![]() Type history Information arq: Architectural Research Quarterly, Volume 13, Issue 2, June 2009, pp. ![]() Compare Standard and Premium Digital here.Īny changes made can be done at any time and will become effective at the end of the trial period, allowing you to retain full access for 4 weeks, even if you downgrade or cancel. The Museum of Innocence is the most recent novel by Pamuk, Turkish novelist and recipient of the 2006 Nobel Prize for Literature (its Turkish title is Masumiyet Mzesi, 2008) 1. ![]() ![]() You may also opt to downgrade to Standard Digital, a robust journalistic offering that fulfils many user’s needs. If you’d like to retain your premium access and save 20%, you can opt to pay annually at the end of the trial. If you do nothing, you will be auto-enrolled in our premium digital monthly subscription plan and retain complete access for $69 per month.įor cost savings, you can change your plan at any time online in the “Settings & Account” section. For a full comparison of Standard and Premium Digital, click here.Ĭhange the plan you will roll onto at any time during your trial by visiting the “Settings & Account” section. ![]() Premium Digital includes access to our premier business column, Lex, as well as 15 curated newsletters covering key business themes with original, in-depth reporting. Standard Digital includes access to a wealth of global news, analysis and expert opinion. During your trial you will have complete digital access to FT.com with everything in both of our Standard Digital and Premium Digital packages. ![]() ![]() ![]() Another section I really enjoyed was when Leigh gives Mr. I love how Cleary is able to capture the voice of this boy, misspellings and all. My teacher read your book about the dog to our class. My favourite letter is the first one, which reads as follows: I love a good epistolary novel… when it works. Yes, I saw them everywhere, but for some reason, I never picked them up. (For some odd reason, I never read Beverly Cleary’s books when I was a kid. And while I knew the ending, I found this book just as interesting to read this second time around. This is probably my second read-through of this book. Through a series of letters (and later a diary), Leigh finds an outlet to work through his problems that range from a lunch-thief to his absentee dad. Henshaw // by Beverly Cleary (1983)īasic Plot: Leigh Botts loves the book Ways to Amuse a Dog so much that he decides to write the author: Mr. ![]() ![]() ![]() “Brat Farrar” is an excellent mix of tightly-written plot and interesting characters against the beautifully evoked backdrop of the English countryside. ![]() ![]() Josephine Tey doesn’t shy away from showing character flaws, though, English snobbery and a sense of entitlement a part of this novel and others. This romantic image of England was often a part of crime fiction of the time, also used to great effect by such writers as Agatha Christie and Dorothy L. She was just beginning to make a life for herself in England when she was called back to Inverness to look after her widowed father and remained living there for the rest of her life. It paints a slightly nostalgic, romantic view of middle-class English life common in a number of Josephine Tey’s books, which might well be explained by the author’s working-class Scottish background. This is a fast-paced psychological mystery novel with well-rounded characters. ![]() The title character is a young man convinced to impersonate Patrick Ashby, the heir to the Latchetts estate, and Brat is increasingly caught up in trying to discover what really happened to Patrick, with deadly consequences. “ Brat Farrar” is a book I loved as a teenager so re-reading it is always like a home-coming. ![]() ![]() “It went from very cool to aaah!” Zahn explained to me last year when I interviewed him for Polygon. When Lucasfilm decided to start publishing new stories in the universe in the late 1989s, Zahn's name ended up on the short list, and he got a call from his agent, asking if he'd be willing to pick up where George Lucas had left off with Return of the Jedi. ![]() ![]() Like most other science fiction fans at the time, he was captivated by Star Wars when he saw it in theaters. By the late 1970s and early 1980s, he had begun to sell those stories to magazines like Analog Science Fiction and Fact, and eventually earned a Hugo Award for his novella Cascade Point in 1983. He had been a fan of science fiction since he was a kid, and when he began to write on his own in college where he was studying physics, it proved to be a natural genre for his stories. Timothy Zahn had never expected to write a Star Wars novel. ![]() But for long-time fans, it was an electrifying moment: Thrawn was an incredibly popular figure in the Star Wars canon, and his journey from print to television series is one that's integral to the current state of the franchise.ģ0 years ago this last weekend, he made his print debut, and changed Star Wars forever. For those who weren't well-read in the Star Wars Expanded Universe, the name might have been a throwaway line, or a hint at some other direction for the series. ![]() ![]() ![]() Now hear the story from his lips: unbarred, uncensored, and raw to the bone. You met Romeo Prince in the Amazon & USA Today bestselling novel, Sweet Home. Mature New Adult novel - contains adult content, highly sexual situations and mature topics. ![]() ![]() When a chance encounter with notorious star quarterback, Romeo Prince, leaves her unable to think of anything but his chocolate-brown eyes, dirty-blond hair and perfect physique, Molly soon realises that her quiet, solitary life is about to dramatically change forever… She knows that the people who love you leave you.īut when Molly leaves England’s grey skies behind to start a new life at the University of Alabama, she finds that she has a lot to learn - she didn’t know a summer could be so hot, she didn’t know students could be so intimidating, and she certainly didn’t know just how much the folks of Alabama love their football. The Sweet Home series by Tillie Cole is on sale for only 99¢ right now and the whole series is moving to Kindle Unlimited!!Īt age twenty, Molly Shakespeare knows a lot. ![]() ![]() I had zero interest in returning to this world after this novel, but for the readers who were interested it’s a shitty way to be manipulated into reading after the three other cliff-hangers. Apparently, this was to hype up the series she’s writing for Hades. To top it all off, James ended Kate on a cliff-hanger regarding Hades’ identify. Unfortunately, the answers weren’t satisfying at all. Kate wraps up the series by finally giving readers answers. The entire series did not need to be four books long. The final novel, Kate, was painful to get through since it did not need to be 592 pages. ![]() If a war is what it takes, then a war is what they’ll get. This is my life, dammit, and these guys are mine to keep. ![]() No matter how much I’ve fought it, hated it, been lied to or discovered the deceptions-I want them in my life. Hate fueled me, lies tore me apart, and in the end everything I thought I knew turned out to be fake.Įxcept… Riot Night also brought Archer, Kody, and Steele back into my life. I’ve been hunted, stabbed, stalked, tormented, and used. ![]() The blurb below may contain spoilers for previous books, and I urge you not to read it until you’ve finished HATE, LIAR and FAKE.Ĭoming back to Shadow Grove turned it on its head. KATE is book 4 of 4 in the MADISON KATE series. Haven’t read the previous novels? Check out reviews of Hate, Liar, and Fake. ![]() ![]() In this course, you’ll learn Macbeth’s story, explore the complex morality and psychology of Macbeth and his accomplice, Lady Macbeth, and hear the play’s key speeches performed and analyzed by world-class Shakespearean actors and literary scholars. Macbeth is a warrior lord living in medieval Scotland who starts the play by saving his king - only to then murder the king himself. Macbeth is one of Shakespeare’s most concentrated and thrilling tragedies. “ Macbeth: A Modern Perspective.” Folger Shakespeare Library. New York: Random House Publishing Group, 2009. Edited by Jonathan Bate and Eric Rasmussen. Howard, Katharine Eisaman Maus and Gordon McMullan. Edited by Stephen Greenblatt, Walter Cohen, Suzanne Gossett, Jean E. “Introduction,” Macbeth, in Shakespeare, William. The particular way Macbeth uses language to explore evil, conscience, and guiltĮpisode 1 - Macbeth: The Story and the HistoryĮpisode 2 - Macbeth: The Characters and the Questions ![]() ![]() The strategies Shakespeare uses to create villainous characters who still retain humanity and sympathy The story of Macbeth and the play’s structure and historical context ![]() |